Diminished exercise capacity and mitochondrial bc1 complex deficiency in tafazzin-knockdown mice.

The phospholipid, cardiolipin, is essential for maintaining mitochondrial structure and optimal function. Cardiolipin-deficiency in humans, Barth syndrome, is characterized by exercise intolerance, dilated cardiomyopathy, neutropenia and 3-methyl-glutaconic aciduria. The causative gene is the mitoch...

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Bibliographic Details
Main Authors: Corey ePowers, Yan eHuang, Arnold W Strauss, Zaza eKhuchua
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00074/full