Melatonin induces RAW264.7 cell apoptosis via the BMAL1/ROS/MAPK-p38 pathway to improve postmenopausal osteoporosis

Melatonin induces RAW264.7 cell apoptosis via the BMAL1/ROS/MAPK-p38 pathway to improve postmenopausal osteoporosis

Aims: Currently, the effect of drug treatment for osteoporosis is relatively poor, and the side effects are numerous and serious. Melatonin is a potential drug to improve bone mass in postmenopausal women. Unfortunately, the mechanism by which melatonin improves bone metabolism remains unclear. The...

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Bibliographic Details
Main Authors: Xiaochuan Wang, Wen Jiang, Kexin Pan, Lin Tao, Yue Zhu
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2023-11-01
Series:Bone & Joint Research
Subjects:
melatonin
osteoporosis
bmal1
ros
postmenopausal osteoporosis
apoptosis
osteoclasts
western blotting
flow cytometry
macrophage
leukaemia
reactive oxygen species
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1211.BJR-2022-0425.R3

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1211.BJR-2022-0425.R3

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