Melatonin induces RAW264.7 cell apoptosis via the BMAL1/ROS/MAPK-p38 pathway to improve postmenopausal osteoporosis

Melatonin induces RAW264.7 cell apoptosis via the BMAL1/ROS/MAPK-p38 pathway to improve postmenopausal osteoporosis

Aims: Currently, the effect of drug treatment for osteoporosis is relatively poor, and the side effects are numerous and serious. Melatonin is a potential drug to improve bone mass in postmenopausal women. Unfortunately, the mechanism by which melatonin improves bone metabolism remains unclear. The...

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Bibliographic Details
Main Authors:	Xiaochuan Wang, Wen Jiang, Kexin Pan, Lin Tao, Yue Zhu
Format:	Article
Language:	English
Published:	The British Editorial Society of Bone & Joint Surgery 2023-11-01
Series:	Bone & Joint Research
Subjects:	melatonin osteoporosis bmal1 ros postmenopausal osteoporosis apoptosis osteoclasts western blotting flow cytometry macrophage leukaemia reactive oxygen species
Online Access:	https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1211.BJR-2022-0425.R3

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