CRISPR Cas13-Based Tools to Track and Manipulate Endogenous Telomeric Repeat-Containing RNAs in Live Cells

CRISPR Cas13-Based Tools to Track and Manipulate Endogenous Telomeric Repeat-Containing RNAs in Live Cells

TERRA, TElomeric Repeat-containing RNA, is a long non-coding RNA transcribed from telomeres. Emerging evidence indicates that TERRA regulates telomere maintenance and chromosome end protection in normal and cancerous cells. However, the mechanism of how TERRA contributes to telomere functions is sti...

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Bibliographic Details
Main Authors: Meng Xu, Tafadzwa Chigumira, Ziheng Chen, Jason Tones, Rongwei Zhao, Kris Noel Dahl, David M. Chenoweth, Huaiying Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
RNA imaging
TERRA
lncRNA
telomere
CRISPR Cas13
chemical dimerizer
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.785160/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.785160/full

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