Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways

Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways

Leukotrienes (LTs) and sphingolipids are critical lipid mediators participating in numerous cellular signal transduction events and developing various disorders, such as bronchial hyperactivity leading to asthma. Enzymatic reactions initiating production of these lipid mediators involve 5-lipoxygena...

Full description

Bibliographic Details
Main Authors: Viktor Bugajev, Tomas Paulenda, Pavol Utekal, Michal Mrkacek, Ivana Halova, Ladislav Kuchar, Ondrej Kuda, Petra Vavrova, Björn Schuster, Sergio Fuentes-Liso, Lucie Potuckova, Daniel Smrz, Sara Cernohouzova, Lubica Draberova, Monika Bambouskova, Petr Draber
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Lipid Research
Subjects:
sphingolipids
leukotrienes
immunology
signal transduction
inflammation
peritoneal-derived mast cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227521001036

Internet

http://www.sciencedirect.com/science/article/pii/S0022227521001036

Similar Items