Design, Synthesis, and Anti-Cervical Cancer and Reversal of Tumor Multidrug Resistance Activity of Novel Nitrogen-Containing Heterocyclic Chalcone Derivatives

Design, Synthesis, and Anti-Cervical Cancer and Reversal of Tumor Multidrug Resistance Activity of Novel Nitrogen-Containing Heterocyclic Chalcone Derivatives

This study involved the design and synthesis of 21 new nitrogen-containing heterocyclic chalcone derivatives utilizing the active substructure splicing principle, with glycyrrhiza chalcone serving as the lead compound. The targets of these derivatives were VEGFR-2 and P-gp, and their efficacy agains...

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Bibliographic Details
Main Authors: Zheng Yang, Zheng-Ye Liu, Mourboul Ablise, Aikebaier Maimaiti, Zuohelaguli Mutalipu, Yusupuwajimu Alimujiang, Aizitiaili Aihaiti
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
azacyclic
glycyrrhiza chalcone
anti-cervical cancer activity
cisplatin resistance
molecular docking
Online Access:https://www.mdpi.com/1420-3049/28/11/4537

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https://www.mdpi.com/1420-3049/28/11/4537

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