αβ-T Cells Engineered to Express γδ-T Cell Receptors Can Kill Neuroblastoma Organoids Independent of MHC-I Expression

αβ-T Cells Engineered to Express γδ-T Cell Receptors Can Kill Neuroblastoma Organoids Independent of MHC-I Expression

Currently ~50% of patients with a diagnosis of high-risk neuroblastoma will not survive due to relapsing or refractory disease. Recent innovations in immunotherapy for solid tumors are highly promising, but the low MHC-I expression of neuroblastoma represents a major challenge for T cell-mediated im...

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Bibliographic Details
Main Authors: Josephine G. M. Strijker, Ronja Pscheid, Esther Drent, Jessica J. F. van der Hoek, Bianca Koopmans, Kimberley Ober, Sander R. van Hooff, Waleed M. Kholosy, Annelisa M. Cornel, Chris Coomans, Andrea Bisso, Marleen M. van Loenen, Jan J. Molenaar, Judith Wienke
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Journal of Personalized Medicine
Subjects:
neuroblastoma
immunotherapy
γδ-T cells
TEG002
MHC-I
Online Access:https://www.mdpi.com/2075-4426/11/9/923

Internet

https://www.mdpi.com/2075-4426/11/9/923

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