Alpinumisoflavone Exhibits the Therapeutic Effect on Prostate Cancer Cells by Repressing AR and Co-Targeting FASN- and HMGCR-Mediated Lipid and Cholesterol Biosynthesis

Alpinumisoflavone Exhibits the Therapeutic Effect on Prostate Cancer Cells by Repressing AR and Co-Targeting FASN- and HMGCR-Mediated Lipid and Cholesterol Biosynthesis

Prostate cancer (PCa) is the most common cancer in men, and this has been mainly noticed in Western and Asian countries. The aggregations of PCa and castration-resistant PCa (CRPC) progression are the crucial causes in the mortality of patients without the effective treatment. To seek new remedies f...

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Bibliographic Details
Main Authors: Praveenkumar Basavaraj, Phakkhathorn Ruangsai, Po-Fan Hsieh, Wen-Ping Jiang, Da-Tian Bau, Guan-Jhong Huang, Wen-Chin Huang
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Life
Subjects:
alpinumisoflavone
androgen receptor
anti-prostate cancer efficacy
apoptosis
fatty acid synthase
3-hydroxy-3-methylglutaryl-CoA reductase
Online Access:https://www.mdpi.com/2075-1729/12/11/1769

Internet

https://www.mdpi.com/2075-1729/12/11/1769

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