Alternagin-C binding to α2β1 integrin controls matrix metalloprotease-9 and matrix metalloprotease-2 in breast tumor cells and endothelial cells

Alternagin-C binding to α2β1 integrin controls matrix metalloprotease-9 and matrix metalloprotease-2 in breast tumor cells and endothelial cells

Abstract Background Matrix metalloproteinases (MMPs) are key players in tumor progression, helping tumor cells to modify their microenvironment, which allows cell migration to secondary sites. The role of integrins, adhesion receptors that connect cells to the extracellular matrix, in MMP expression...

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Bibliographic Details
Main Authors: Milene Nóbrega de Oliveira Moritz, Lívia Mara Santos Eustáquio, Kelli Cristina Micocci, Ana Carolina Caetano Nunes, Patty Karina dos Santos, Tamires de Castro Vieira, Heloísa Sobreiro Selistre-de-Araujo
Format: Article
Language:English
Published: SciELO 2018-04-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
ALT-C
α2β1 integrin
Cancer
Tumor microenvironment
MMP
C-Myc
Online Access:http://link.springer.com/article/10.1186/s40409-018-0150-2

Internet

http://link.springer.com/article/10.1186/s40409-018-0150-2

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