Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens

Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens

Mast cell activators are a novel class of mucosal vaccine adjuvants. The polymeric compound, Compound 48/80 (C48/80), and cationic peptide, Mastoparan 7 (M7) are mast cell activators that provide adjuvant activity when administered by the nasal route. However, small molecule mast cell activators may...

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Bibliographic Details
Main Authors: Brandi T. Johnson-Weaver, Hae Woong Choi, Hang Yang, Josh A. Granek, Cliburn Chan, Soman N. Abraham, Herman F. Staats
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
vaccine adjuvants
nasal vaccine
mast cells
small molecule adjuvants
adjuvant discovery
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.730346/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.730346/full

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