LncRNA TINCR impairs the efficacy of immunotherapy against breast cancer by recruiting DNMT1 and downregulating MiR-199a-5p via the STAT1–TINCR-USP20-PD-L1 axis

LncRNA TINCR impairs the efficacy of immunotherapy against breast cancer by recruiting DNMT1 and downregulating MiR-199a-5p via the STAT1–TINCR-USP20-PD-L1 axis

Abstract Although programmed death-ligand 1 (PD-L1) inhibitors have achieved some therapeutic success in breast cancer, their efficacy is limited by low therapeutic response rates, which is closely related to the immune escape of breast cancer cells. Tissue differentiation inducing non-protein codin...

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Bibliographic Details
Main Authors: Qin Wang, Guozheng Li, Xin Ma, Lei Liu, Jiena Liu, Yanling Yin, Hui Li, Yihai Chen, Xin Zhang, Lei Zhang, Liyang Sun, Jing Ai, Shouping Xu
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05609-2

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https://doi.org/10.1038/s41419-023-05609-2

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