CaV3.1 channels facilitate calcium wave generation and myogenic tone development in mouse mesenteric arteries

Abstract The arterial myogenic response to intraluminal pressure elicits constriction to maintain tissue perfusion. Smooth muscle [Ca2+] is a key determinant of constriction, tied to L-type (CaV1.2) Ca2+ channels. While important, other Ca2+ channels, particularly T-type could contribute to pressure...

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Bibliographic Details
Main Authors: Mohammed A. El-Lakany, Nadia Haghbin, Naman Arora, Ahmed M. Hashad, Galina Yu. Mironova, Maria Sancho, Robert Gros, Donald G. Welsh
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-47715-3