Mutations in the promoter region of methionine transporter gene metM (Rv3253c) confer para-aminosalicylic acid (PAS) resistance in Mycobacterium tuberculosis

Mutations in the promoter region of methionine transporter gene metM (Rv3253c) confer para-aminosalicylic acid (PAS) resistance in Mycobacterium tuberculosis

ABSTRACT Tuberculosis (TB) is a significant global public health threat. Despite the long-standing use of para-aminosalicylic acid (PAS) as a second-line anti-TB drug, its resistance mechanism remains unclear. In this study, we isolated 90 mutants of PAS-resistant Mycobacterium tuberculosis (MTB) H3...

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Bibliographic Details
Main Authors: Yu Zhang, Shiyong Wang, Xinchang Chen, Peng Cui, Jiazhen Chen, Wenhong Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
Mycobacterium tuberculosis
resistance
para-aminosalicylic acid
metM promoter
methionine
Online Access:https://journals.asm.org/doi/10.1128/mbio.02073-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02073-23

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