CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

Abstract Lentiviral vectors (LV) have become the dominant tool for stable gene transfer into lymphocytes including chimeric antigen receptor (CAR) gene delivery to T cells, a major breakthrough in cancer therapy. Yet, room for improvement remains, especially for the latest LV generations delivering...

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Bibliographic Details
Main Authors: Filippos T Charitidis, Elham Adabi, Naphang Ho, Angela H Braun, Ciara Tierney, Lisa Strasser, Frederic B Thalheimer, Liam Childs, Jonathan Bones, Colin Clarke, Christian J Buchholz
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Advanced Science
Subjects:
CAR T cells
IFITM
in vivo gene delivery
rapamycin
receptor‐targeted vectors
transduction enhancer
Online Access:https://doi.org/10.1002/advs.202302992

Internet

https://doi.org/10.1002/advs.202302992

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