Differential effects of ketoconazole, fluconazole, and itraconazole on the pharmacokinetics of pyrotinib in vitro and in vivo

Differential effects of ketoconazole, fluconazole, and itraconazole on the pharmacokinetics of pyrotinib in vitro and in vivo

It has been reported that drug-drug interactions (DDIs) can affect the pharmacokinetics and pharmacodynamics of various oral drugs. To better understand the effects of azole antifungal drugs (ketoconazole, fluconazole, and itraconazole) on pyrotinib’s pharmacokinetics, DDIs between pyrotinib and thr...

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Bibliographic Details
Main Authors: Li Wang, Fan Wu, Jia Xu, Yu Wang, Weidong Fei, Hui Jiang, Peiwu Geng, Quan Zhou, Shuanghu Wang, Yongquan Zheng, Huadong Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
pyrotinib
drug-drug interaction
metabolism
pharmacokinetics
CYP3A4
azole antifungal
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.962731/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.962731/full

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