Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons

Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons

Abstract Background Venezuelan Equine Encephalitis virus (VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that originate in the nasal cavity after intranasal exposure. While it is known that VEEV has evolved several mechanisms to inhibit type I interferon (IFN...

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Bibliographic Details
Main Authors: Matthew D. Cain, N. Rubin Klein, Xiaoping Jiang, Hamid Salimi, Qingping Wu, Mark J. Miller, William B. Klimstra, Robyn S. Klein
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-023-02960-1

Internet

https://doi.org/10.1186/s12974-023-02960-1

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