Small extracellular vesicles derived from human adipose‐derived mesenchymal stromal cells cultured in a new chemically‐defined contaminate‐free media exhibit enhanced biological and therapeutic effects on human chondrocytes in vitro and in a mouse osteoarthritis model

Small extracellular vesicles derived from human adipose‐derived mesenchymal stromal cells cultured in a new chemically‐defined contaminate‐free media exhibit enhanced biological and therapeutic effects on human chondrocytes in vitro and in a mouse osteoarthritis model

Abstract Human small extracellular vesicles (sEVs) derived from adipose‐derived mesenchymal stromal cells (ASC) have been reported to suppress the progression of osteoarthritis (OA) in animal studies and subsequently, translation of this potential to assess their clinical efficacy is anticipated. Ho...

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Bibliographic Details
Main Authors: Hiroto Hanai, David A. Hart, George Jacob, Kazunori Shimomura, Wataru Ando, Yusuke Yoshioka, Takahiro Ochiya, Shinicihi Nakagawa, Masato Nakamura, Seiji Okada, Norimasa Nakamura
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Journal of Extracellular Vesicles
Subjects:
adipose‐derived mesenchymal stromal cells
chemically‐defined media
exosomes
extracellular vesicles
human articular chondrocytes
osteoarthritis
Online Access:https://doi.org/10.1002/jev2.12337

Internet

https://doi.org/10.1002/jev2.12337

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