Hypoxia Inhibits Subretinal Inflammation Resolution Thrombospondin-1 Dependently

Hypoxia Inhibits Subretinal Inflammation Resolution Thrombospondin-1 Dependently

Hypoxia is potentially one of the essential triggers in the pathogenesis of wet age-related macular degeneration (wetAMD), characterized by choroidal neovascularization (CNV) which is driven by the accumulation of subretinal mononuclear phagocytes (MP) that include monocyte-derived cells. Here we sh...

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Bibliographic Details
Main Authors: Sara Touhami, Fanny Béguier, Tianxiang Yang, Sébastien Augustin, Christophe Roubeix, Frederic Blond, Jean Baptiste Conart, José Alain Sahel, Bahram Bodaghi, Cécile Delarasse, Xavier Guillonneau, Florian Sennlaub
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
age-related macular degeneration
hypoxia
macrophages
mononuclear phagocytes
choroidal neovascularization
thrombospondin 1
Online Access:https://www.mdpi.com/1422-0067/23/2/681

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https://www.mdpi.com/1422-0067/23/2/681

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