Subtle structural differences of nucleotide analogs may impact SARS-CoV-2 RNA-dependent RNA polymerase and exoribonuclease activity

Subtle structural differences of nucleotide analogs may impact SARS-CoV-2 RNA-dependent RNA polymerase and exoribonuclease activity

The rapid spread and public health impact of the novel SARS-CoV-2 variants that cause COVID-19 continue to produce major global impacts and social distress. Several vaccines were developed in record time to prevent and limit the spread of the infection, thus playing a pivotal role in controlling the...

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Bibliographic Details
Main Authors: Abraham Madariaga-Mazón, José J. Naveja, Arturo Becerra, José Alberto Campillo-Balderas, Ricardo Hernández-Morales, Rodrigo Jácome, Antonio Lazcano, Karina Martinez-Mayorga
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
SARS-CoV-2
RNA-dependent RNA polymerase
Exoribonuclease
Nucleotide analogs
Molecular modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022003907

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http://www.sciencedirect.com/science/article/pii/S2001037022003907

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