Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endothelial Dysfunction in Rat Aortic Rings

Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endothelial Dysfunction in Rat Aortic Rings

The uremic toxin indoxyl sulfate (IS), elevated in chronic kidney disease (CKD), is known to contribute towards progressive cardiovascular disease. IS activates the aryl hydrocarbon receptor (AhR) mediating oxidative stress and endothelial dysfunction via activation of the CYP1A1 pathway. The presen...

Full description

Bibliographic Details
Main Authors: Cindy Nguyen, Amanda J. Edgley, Darren J. Kelly, Andrew R. Kompa
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Toxins
Subjects:
aryl hydrocarbon receptor
indoxyl sulfate
endothelial dysfunction
chronic kidney disease
cardiovascular disease
oxidative stress
Online Access:https://www.mdpi.com/2072-6651/14/2/100

Internet

https://www.mdpi.com/2072-6651/14/2/100

Similar Items