Effects of G-Quadruplex-Binding Plant Secondary Metabolites on <i>c-MYC</i> Expression

Effects of G-Quadruplex-Binding Plant Secondary Metabolites on <i>c-MYC</i> Expression

Guanine-rich DNA sequences tending to adopt noncanonical G-quadruplex (G4) structures are over-represented in promoter regions of oncogenes. Ligands recognizing G4 were shown to stabilize these DNA structures and drive their formation regulating expression of corresponding genes. We studied the inte...

Full description

Bibliographic Details
Main Authors: Roman G. Zenkov, Kirill I. Kirsanov, Anna M. Ogloblina, Olga A. Vlasova, Denis S. Naberezhnov, Natalia Y. Karpechenko, Timur I. Fetisov, Ekaterina A. Lesovaya, Gennady A. Belitsky, Nina G. Dolinnaya, Marianna G. Yakubovskaya
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
G-quadruplex
G4-binding ligands
plant secondary metabolites
luciferase reporter assay
<i>c-MYC</i> promoter
fluorescent indicator displacement
Online Access:https://www.mdpi.com/1422-0067/23/16/9209

Internet

https://www.mdpi.com/1422-0067/23/16/9209

Similar Items