A disrupted FOXP3 transcriptional signature underpins systemic regulatory T cell insufficiency in early pregnancy failure

A disrupted FOXP3 transcriptional signature underpins systemic regulatory T cell insufficiency in early pregnancy failure

Summary: Regulatory T (Treg) cell defects are implicated in disorders of embryo implantation and placental development, but the origins of Treg cell dysfunction are unknown. Here, we comprehensively analyzed the phenotypes and transcriptional profile of peripheral blood Treg cells in individuals wit...

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Bibliographic Details
Main Authors: Lachlan M. Moldenhauer, Kerrie L. Foyle, Jasmine J. Wilson, Ying Y. Wong, David J. Sharkey, Ella S. Green, Simon C. Barry, M. Louise Hull, Sarah A. Robertson
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Health sciences
Pregnancy
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224002153

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224002153

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