Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers–Danlos syndrome

Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers–Danlos syndrome

Abstract Deficiency of an extracellular matrix glycoprotein tenascin-X (TNX) leads to a human heritable disorder Ehlers–Danlos syndrome, and TNX-deficient patients complain of chronic joint pain, myalgia, paresthesia, and axonal polyneuropathy. We previously reported that TNX-deficient (Tnxb −/− ) m...

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Bibliographic Details
Main Authors: Hiroki Kamada, Kousuke Emura, Rikuto Yamamoto, Koichi Kawahara, Sadahito Uto, Toshiaki Minami, Seiji Ito, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45638-7

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https://doi.org/10.1038/s41598-023-45638-7

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