Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability

Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability

Abstract Background Epithelial-mesenchymal transition (EMT) may be one of the reasons for the failure in some clinical trials regarding histone deacetylase inhibitors (HDACIs)-treated solid tumors. We investigated the effects of a pan-HDACI trichostatin A (TSA) on the proliferation and EMT of nasoph...

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Bibliographic Details
Main Authors: Zhihua Shen, Xiaomin Liao, Zhongming Shao, Muyin Feng, Jianling Yuan, Sisi Wang, Siyuan Gan, Yanping Ha, Zhiwei He, Wei Jie
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Cancer
Subjects:
Nasopharyngeal carcinoma
Histone deacetylase inhibitor
Trichostatin a
ITSA-1
Epithelial mesenchymal transition
Proliferation
Online Access:http://link.springer.com/article/10.1186/s12885-019-5482-y

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http://link.springer.com/article/10.1186/s12885-019-5482-y

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