JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships

JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships

Abstract 2-Oxoglutarate (2OG) dependent N ε -methyl lysine demethylases (JmjC-KDMs) regulate eukaryotic transcription. We report studies showing that isolated forms of all human KDM4 and KDM5 JmjC enzymes catalyse demethylation of N-methylated Arg-3 of histone H2a. Unexpectedly, the results reveal t...

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Bibliographic Details
Main Authors: Joanna Bonnici, Razanne Oueini, Eidarus Salah, Catrine Johansson, Elisabete Pires, Martine Abboud, Robert S. Dawber, Anthony Tumber, Patrick Rabe, Hilal Saraç, Christopher J. Schofield, Akane Kawamura
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07183-5

Internet

https://doi.org/10.1038/s42003-024-07183-5

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