The Happy Hopping of Transposons: The Origins of V(D)J Recombination in Adaptive Immunity

The Happy Hopping of Transposons: The Origins of V(D)J Recombination in Adaptive Immunity

Nearly 50% of the human genome is derived from transposable elements (TEs). Though dysregulated transposons are deleterious to humans and can lead to diseases, co-opted transposons play an important role in generating alternative or new DNA sequence combinations to perform novel cellular functions....

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Bibliographic Details
Main Authors: Rishi V. Shridharan, Neha Kalakuntla, Narendra Chirmule, Bhavana Tiwari
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Ecology and Evolution
Subjects:
transposable elements
V(D)J recombination
adaptive immunity
RAG recombinase
DNA transposons
Online Access:https://www.frontiersin.org/articles/10.3389/fevo.2022.836066/full

Internet

https://www.frontiersin.org/articles/10.3389/fevo.2022.836066/full

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