A Systematic Review Comparing Experimental Design of Animal and Human Methotrexate Efficacy Studies for Rheumatoid Arthritis: Lessons for the Translational Value of Animal Studies

A Systematic Review Comparing Experimental Design of Animal and Human Methotrexate Efficacy Studies for Rheumatoid Arthritis: Lessons for the Translational Value of Animal Studies

Increased awareness and understanding of current practices in translational research is required for informed decision making in drug development. This paper describes a systematic review of methotrexate for rheumatoid arthritis, comparing trial design between 147 animal and 512 human studies. Anima...

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Bibliographic Details
Main Authors: Cathalijn Leenaars, Frans Stafleu, David de Jong, Maikel van Berlo, Tijmen Geurts, Tineke Coenen-de Roo, Jan-Bas Prins, Rosalie Kempkes, Janneke Elzinga, André Bleich, Rob de Vries, Franck Meijboom, Merel Ritskes-Hoitinga
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Animals
Subjects:
Systematic review
experimental design
animal-to-human translation
rheumatoid arthritis
methotrexate
Online Access:https://www.mdpi.com/2076-2615/10/6/1047

Internet

https://www.mdpi.com/2076-2615/10/6/1047

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