Prolonged Primary Rhinovirus Infection of Human Nasal Epithelial Cells Diminishes the Viral Load of Secondary Influenza H3N2 Infection via the Antiviral State Mediated by RIG-I and Interferon-Stimulated Genes

Prolonged Primary Rhinovirus Infection of Human Nasal Epithelial Cells Diminishes the Viral Load of Secondary Influenza H3N2 Infection via the Antiviral State Mediated by RIG-I and Interferon-Stimulated Genes

Our previous study revealed that prolonged human rhinovirus (HRV) infection rapidly induces antiviral interferons (IFNs) and chemokines during the acute stage of infection. It also showed that expression levels of RIG-I and interferon-stimulated genes (ISGs) were sustained in tandem with the persist...

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Bibliographic Details
Main Authors: Hsiao Hui Ong, Jing Liu, Yukei Oo, Mark Thong, De Yun Wang, Vincent T. Chow
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
human nasal epithelium
rhinovirus persistence
secondary influenza virus infection
rhinovirus re-infection
innate immune responses
RIG-I
Online Access:https://www.mdpi.com/2073-4409/12/8/1152

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https://www.mdpi.com/2073-4409/12/8/1152

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