Enantioselective Evans-Tishchenko Reduction of b-Hydroxyketone Catalyzed by Lithium Binaphtholate

Enantioselective Evans-Tishchenko Reduction of b-Hydroxyketone Catalyzed by Lithium Binaphtholate

Lithium diphenylbinaphtholate catalyzed the enantioselective Evans-Tishchenko reduction of achiral b-hydroxyketones to afford monoacyl-protected 1,3-diols with high stereoselectivities. In the reaction of racemic b-hydroxyketones, kinetic optical resolution occurred in a highly stereoselective manne...

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Bibliographic Details
Main Authors: Makoto Nakajima, Tomonori Ichibakase, Masato Nakatsu
Format: Article
Language:English
Published: MDPI AG 2011-06-01
Series:Molecules
Subjects:
Evans-Tishchenko reduction
lithium binaphtholate
b-hydroxyketone
1,3-diol
enantioselectivity
Online Access:http://www.mdpi.com/1420-3049/16/6/5008/

Internet

http://www.mdpi.com/1420-3049/16/6/5008/

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