Glioma Stem Cells Are Sensitized to BCL-2 Family Inhibition by Compromising Histone Deacetylases

Glioma Stem Cells Are Sensitized to BCL-2 Family Inhibition by Compromising Histone Deacetylases

Glioblastoma (GBM) remains an incurable disease with an extremely high five-year recurrence rate. We studied apoptosis in glioma stem cells (GSCs) in response to HDAC inhibition (HDACi) combined with MEK1/2 inhibition (MEKi) or BCL-2 family inhibitors. MEKi effectively combined with HDACi to suppres...

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Bibliographic Details
Main Authors: Aran Merati, Spandana Kotian, Alexus Acton, William Placzek, Erin Smithberger, Abigail K. Shelton, C. Ryan Miller, Josh L. Stern
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma
apoptosis
HDAC inhibitor
BIM
BMF
BCL-2 family
Online Access:https://www.mdpi.com/1422-0067/24/18/13688

Internet

https://www.mdpi.com/1422-0067/24/18/13688

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