Aβ42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood–brain barrier model

Aβ42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood–brain barrier model

Abstract Our previous study showed that the flotillin level is decreased in the blood of patients with Alzheimer’s disease (AD) when compared to that of patients with non-AD and vascular dementia; however, the molecular mechanism remains to be determined. In this study, to elucidate whether Aβ accum...

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Bibliographic Details
Main Authors: Tomohisa Nakamura, Tadahiro Hashita, Yuxin Chen, Yuan Gao, Yang Sun, Sadequl Islam, Hiroyuki Sato, Yasuyuki Shibuya, Kun Zou, Tamihide Matsunaga, Makoto Michikawa
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Molecular Brain
Subjects:
Amyloid β-protein
Alzheimer’s disease
Blood flotillin
Microvascular endothelial cells
Online Access:https://doi.org/10.1186/s13041-023-01005-1

Internet

https://doi.org/10.1186/s13041-023-01005-1

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