The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells

The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells

Abstract Background As a well-characterized key player in various signal transduction networks, extracellular-signal-regulated kinase (ERK1/2) has been widely implicated in the development of many malignancies. We previously found that Leucine-rich repeat containing 4 (LRRC4) was a tumor suppressor...

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Bibliographic Details
Main Authors: Zeyou Wang, Qin Guo, Rong Wang, Gang Xu, Peiyao Li, Yingnan Sun, Xiaoling She, Qiang Liu, Qiong Chen, Zhibin Yu, Changhong Liu, Jing Xiong, Guiyuan Li, Minghua Wu
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Journal of Hematology & Oncology
Subjects:
Leucine-rich repeat
D domain
CD domain
ERK1/2
MAPK
Online Access:http://link.springer.com/article/10.1186/s13045-016-0355-1

Internet

http://link.springer.com/article/10.1186/s13045-016-0355-1

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