Measuring aggregates, self-association, and weak interactions in concentrated therapeutic antibody solutions

Measuring aggregates, self-association, and weak interactions in concentrated therapeutic antibody solutions

Monoclonal antibodies are a class of biotherapeutics used for an increasing variety of disorders, including cancer, autoimmune, neurodegenerative, and viral diseases. Besides their antigen specificity, therapeutic use also mandates control of their solution interactions and colloidal properties in o...

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Bibliographic Details
Main Authors: Sumit K. Chaturvedi, Arun Parupudi, Kristian Juul-Madsen, Ai Nguyen, Thomas Vorup-Jensen, Sonia Dragulin-Otto, Huaying Zhao, Reza Esfandiary, Peter Schuck
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Trace aggregation
nonideality
virial coefficient
self-association
hydrodynamics
protein interactions
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1810488

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2020.1810488

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