Assessment of the cytolytic potential of a multivirus-targeted T cell therapy using a vital dye-based, flow cytometric assay

Assessment of the cytolytic potential of a multivirus-targeted T cell therapy using a vital dye-based, flow cytometric assay

Reliable and sensitive characterization assays are important determinants of the successful clinical translation of immunotherapies. For the assessment of cytolytic potential, the chromium 51 (51Cr) release assay has long been considered the gold standard for testing effector cells. However, attaini...

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Bibliographic Details
Main Authors: Kiriakos Koukoulias, Penelope G. Papayanni, Julia Jones, Manik Kuvalekar, Ayumi Watanabe, Yovana Velazquez, Sarah Gilmore, Anastasia Papadopoulou, Ann M. Leen, Spyridoula Vasileiou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
viral infection
adoptive T cell immunotherapy
virus specific T cells (VSTs)
potency assays
T cell cytotoxicity
chromium release assay
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1299512/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1299512/full

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