Glutaminolysis is Essential for Energy Production and Ion Transport in Human Corneal Endothelium

Glutaminolysis is Essential for Energy Production and Ion Transport in Human Corneal Endothelium

Corneal endothelium (CE) is among the most metabolically active tissues in the body. This elevated metabolic rate helps the CE maintain corneal transparency by its ion and fluid transport properties, which when disrupted, leads to visual impairment. Here we demonstrate that glutamine catabolism (glu...

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Bibliographic Details
Main Authors: Wenlin Zhang, Hongde Li, Diego G. Ogando, Shimin Li, Matthew Feng, Francis W. Price, Jr, Jason M. Tennessen, Joseph A. Bonanno
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:EBioMedicine
Subjects:
Glutaminolysis
Energy metabolism
Corneal endothelium
SLC4A11 ammonia transporter
Congenital hereditary endothelial dystrophy (CHED)
Fuchs' endothelial corneal dystrophy (FECD)
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641730004X

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http://www.sciencedirect.com/science/article/pii/S235239641730004X

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