Caudal–Rostral Progression of Alpha Motoneuron Degeneration in the SOD1<sup>G93A</sup> Mouse Model of Amyotrophic Lateral Sclerosis

Caudal–Rostral Progression of Alpha Motoneuron Degeneration in the SOD1<sup>G93A</sup> Mouse Model of Amyotrophic Lateral Sclerosis

Mice with transgenic expression of human SOD1<sup>G93A</sup> are a widely used model of ALS, with a caudal–rostral progression of motor impairment. Previous studies have quantified the progression of motoneuron (MN) degeneration based on size, even though alpha (α-) and gamma (γ-) MNs ov...

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Bibliographic Details
Main Authors: Alastair J. Kirby, Thomas Palmer, Richard J. Mead, Ronaldo M. Ichiyama, Samit Chakrabarty
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Antioxidants
Subjects:
alpha motoneuron
gamma motoneuron
cortical spinal tract
corticofugal synaptopathy
Online Access:https://www.mdpi.com/2076-3921/11/5/983

Internet

https://www.mdpi.com/2076-3921/11/5/983

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