Genome-wide CRISPR screen for HSV-1 host factors reveals PAPSS1 contributes to heparan sulfate synthesis

Genome-wide CRISPR screen for HSV-1 host factors reveals PAPSS1 contributes to heparan sulfate synthesis

A genome-wide CRISPR screen for HSV-1 host factors using near-haploid HAP1 cells revealed PAPSS1 as an essential factor for heparan sulfate biosynthesis and HSV-1 infection, and identified several other host factors also involved in both processes.

Bibliographic Details
Main Authors: Takeshi Suzuki, Yoshitaka Sato, Yusuke Okuno, Fumi Goshima, Tadahisa Mikami, Miki Umeda, Takayuki Murata, Takahiro Watanabe, Koichi Watashi, Takaji Wakita, Hiroshi Kitagawa, Hiroshi Kimura
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03581-9

Internet

https://doi.org/10.1038/s42003-022-03581-9

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