Differential Susceptibility of Fetal Retinal Pigment Epithelial Cells, hiPSC- Retinal Stem Cells, and Retinal Organoids to Zika Virus Infection

Differential Susceptibility of Fetal Retinal Pigment Epithelial Cells, hiPSC- Retinal Stem Cells, and Retinal Organoids to Zika Virus Infection

Zika virus (ZIKV) causes microcephaly and congenital eye disease. The cellular and molecular basis of congenital ZIKV infection are not well understood. Here, we utilized a biologically relevant cell-based system of human fetal retinal pigment epithelial cells (FRPEs), hiPSC-derived retinal stem cel...

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Bibliographic Details
Main Authors: Deisy Contreras, Gustavo Garcia, Melissa Kaye Jones, Laura E. Martinez, Akshaya Jayakarunakaran, Vineela Gangalapudi, Jie Tang, Ying Wu, Jiagang J. Zhao, Zhaohui Chen, Arunachalam Ramaiah, Irena Tsui, Ashok Kumar, Karin Nielsen-Saines, Shaomei Wang, Vaithilingaraja Arumugaswami
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
Zika virus
human fetal retinal pigment epithelial cells
human iPSC-derived retinal stem cells
retinal organoids
congenital eye disease
apoptosis
Online Access:https://www.mdpi.com/1999-4915/15/1/142

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https://www.mdpi.com/1999-4915/15/1/142

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