Rationally Designed Novel Phenyloxazoline Synthase Inhibitors: Chemical Synthesis and Biological Evaluation to Accelerate the Discovery of New Antimycobacterial Antibiotics

Rationally Designed Novel Phenyloxazoline Synthase Inhibitors: Chemical Synthesis and Biological Evaluation to Accelerate the Discovery of New Antimycobacterial Antibiotics

The uncontrolled spread of drug-resistant tuberculosis (DR-TB) clinical cases necessitates the urgent discovery of newer chemotypes with novel mechanisms of action. Here, we report the chemical synthesis of rationally designed novel transition-state analogues (TSAs) by targeting the cyclization (Cy)...

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Bibliographic Details
Main Authors: Mousumi Shyam, Gourab Bhattacharje, Chris Daniel, Amrendra Kumar, Pragya Yadav, Piyali Mukherjee, Samsher Singh, Amit Kumar Das, Tadigoppula Narender, Amit Singh, Venkatesan Jayaprakash, Sanjib Bhakta
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
mycobactin metabolism
phenyloxazoline synthase
cyclization domain
transition-state analogues
MD simulations
MMPBSA studies
Online Access:https://www.mdpi.com/1420-3049/28/24/8115

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https://www.mdpi.com/1420-3049/28/24/8115

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