Synthesis, Leishmanicidal Activity and Theoretical Evaluations of a Series of Substituted bis-2-Hydroxy-1,4-Naphthoquinones

Synthesis, Leishmanicidal Activity and Theoretical Evaluations of a Series of Substituted bis-2-Hydroxy-1,4-Naphthoquinones

A series of eight substituted bis-2-hydroxy-1,4-naphthoquinone derivatives was synthesized through lawsone condensation with various aromatic and aliphatic aldehydes under mild acidic conditions. The title compounds were evaluated for antileishmanial activity in vitro against Leishmania amazonensis...

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Bibliographic Details
Main Authors: Morgana V. de Araújo, Patricia S. O. de Souza, Aline C. de Queiroz, Carolina B. B. da Matta, Anderson Brandão Leite, Amanda Evelyn da Silva, José A. A. de França, Tania M. S. Silva, Celso A. Camara, Magna S. Alexandre-Moreira
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Molecules
Subjects:
naphthoquinones
knoevenagel
bis-2-hydroxy-1,4-naphthoquinones
antileishmanial activity
Leishmania braziliensis
Leishmania amazonensis
Online Access:http://www.mdpi.com/1420-3049/19/9/15180

Internet

http://www.mdpi.com/1420-3049/19/9/15180

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