Expression of CD47 and SIRPα Macrophage Immune-Checkpoint Pathway in Non-Small-Cell Lung Cancer

Expression of CD47 and SIRPα Macrophage Immune-Checkpoint Pathway in Non-Small-Cell Lung Cancer

Background: Cancer cells escape macrophage phagocytosis by expressing the CD47 integrin-associated protein that binds to the SIRPα ligand (signal regulatory protein alpha) expressed by macrophages. Immunotherapy targeting this pathway is under clinical development. Methods: We investigated the expre...

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Bibliographic Details
Main Authors: Alexandra Giatromanolaki, Achilleas Mitrakas, Ioannis Anestopoulos, Andreas Kontosis, Ioannis M. Koukourakis, Aglaia Pappa, Mihalis I. Panayiotidis, Michael I. Koukourakis
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
lung cancer
CD47
SIRPα
CD68
PD-L1
FOXP3
Online Access:https://www.mdpi.com/2072-6694/14/7/1801

Internet

https://www.mdpi.com/2072-6694/14/7/1801

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