Serotype b of Aggregatibacter actinomycetemcomitans triggers pro-inflammatory responses and amyloid beta secretion in hippocampal cells: a novel link between periodontitis and Alzheimer´s disease?

Serotype b of Aggregatibacter actinomycetemcomitans triggers pro-inflammatory responses and amyloid beta secretion in hippocampal cells: a novel link between periodontitis and Alzheimer´s disease?

Introduction: Previous reports have proposed that Periodontal disease (PDis) predisposes to Alzheimer’s disease (AD), both highly prevalent pathologies among the elderly. The bacteria Aggregatibacter actinomycetemcomitans (Aa), associated with the most aggressive forms of PDis, are classified in dif...

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Bibliographic Details
Main Authors: J. Díaz-Zúñiga, Y. Muñoz, S. Melgar-Rodríguez, J. More, B. Bruna, P. Lobos, G. Monasterio, R. Vernal, A. Paula-Lima
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Oral Microbiology
Subjects:
periodontitis
alzheimer´s disease
inflammation
cytokines
microglia
neurons
Online Access:http://dx.doi.org/10.1080/20002297.2019.1586423

Internet

http://dx.doi.org/10.1080/20002297.2019.1586423

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