Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesis
The insulin-like growth factor-2 (Igf2)-H19 locus encodes important paternally imprinted genes that govern normal embryonic development. While Igf-2 encodes IGF2, which is an autocrine/paracrine mitogen, transcription of H19 gives rise to non-coding mRNA that is a precursor of several microRNAs (mi...
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| Format: | Article |
| Language: | English |
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Via Medica
2012-07-01
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| Series: | Folia Histochemica et Cytobiologica |
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| Online Access: | http://czasopisma.viamedica.pl/fhc/article/view/19347 |