SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation

SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation

SOCS1 deficiency, which increases susceptibility to hepatocellular carcinoma (HCC), promotes CDKN1A expression in the liver. High CDKN1A expression correlates with disease severity in many cancers. Here, we demonstrate a crucial pathogenic role of CDKN1A in diethyl nitrosamine (DEN)-induced HCC in S...

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Bibliographic Details
Main Authors: Md Gulam Musawwir Khan, Nadia Boufaied, Mehdi Yeganeh, Rajani Kandhi, Stephanie Petkiewicz, Ankur Sharma, Akihiko Yoshimura, Gerardo Ferbeyre, David P. Labbé, Sheela Ramanathan, Subburaj Ilangumaran
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
hepatocellular carcinoma
SOCS1
CDKN1A
SOCS3
p53
NRF2
Online Access:https://www.mdpi.com/2072-6694/15/3/905

Internet

https://www.mdpi.com/2072-6694/15/3/905

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