P2X7 receptor inhibition ameliorates ubiquitin–proteasome system dysfunction associated with Alzheimer’s disease

P2X7 receptor inhibition ameliorates ubiquitin–proteasome system dysfunction associated with Alzheimer’s disease

Abstract Background Over recent years, increasing evidence suggests a causal relationship between neurofibrillary tangles (NFTs) formation, the main histopathological hallmark of tauopathies, including Alzheimer’s disease (AD), and the ubiquitin–proteasome system (UPS) dysfunction detected in these...

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Bibliographic Details
Main Authors: Carolina Bianchi, Beatriz Alvarez-Castelao, Álvaro Sebastián-Serrano, Caterina Di Lauro, Lucia Soria-Tobar, Annette Nicke, Tobias Engel, Miguel Díaz-Hernández
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
P2X7 receptor
Ubiquitin–proteasome system
Online Access:https://doi.org/10.1186/s13195-023-01258-x

Internet

https://doi.org/10.1186/s13195-023-01258-x

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