The Application of Peptide Nucleic Acids (PNA) in the Inhibition of Proprotein Convertase Subtilisin/Kexin 9 (<i>PCSK9</i>) Gene Expression in a Cell-Free Transcription/Translation System

The Application of Peptide Nucleic Acids (PNA) in the Inhibition of Proprotein Convertase Subtilisin/Kexin 9 (<i>PCSK9</i>) Gene Expression in a Cell-Free Transcription/Translation System

Proprotein convertase subtilisin/kexin 9 (PCSK9) is a protein that plays a key role in the metabolism of low-density lipoprotein (LDL) cholesterol. The gain-of-function mutations of the <i>PCSK9</i> gene lead to a reduced number of surface LDL receptors by binding to them, eventually lea...

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Bibliographic Details
Main Authors: Agnieszka Polak, Grzegorz Machnik, Łukasz Bułdak, Jarosław Ruczyński, Katarzyna Prochera, Oliwia Bujak, Piotr Mucha, Piotr Rekowski, Bogusław Okopień
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
proprotein convertase subtilisin/kexin 9 (PCSK9)
peptide nucleic acids (PNA)
antigene activity
transcription
translation
Online Access:https://www.mdpi.com/1422-0067/25/3/1463

Internet

https://www.mdpi.com/1422-0067/25/3/1463

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