Antifungal Activity, Cytotoxicity and Mechanism of Action of Nitroheteroaryl-1,3,4-thiadiazole Containing N-benzyl and N-methoxyethyl Substitution Against Aspergillus fumigatus

Antifungal Activity, Cytotoxicity and Mechanism of Action of Nitroheteroaryl-1,3,4-thiadiazole Containing N-benzyl and N-methoxyethyl Substitution Against Aspergillus fumigatus

Introduction: This study aimed to evaluate antifungal activity and cytotoxicity of two new nitroheteroaryl-1,3,4-thiadiazole derivatives containing N-methoxyethyl (9) and N-benzyl (10) moiety against Aspergillus fumigatus with a special focus on their mechanism of action at cellular level. Material...

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Bibliographic Details
Main Authors: Pegah MORADABAD, Azar TAHGHIGHI, Leili JALILI-BALEH, Alireza FOROUMADI, Masoomeh SHAMS-GHAHFAROKHI, Mehdi RAZZAGHI-ABYANEH
Format: Article
Language:Turkish
Published: Galenos Yayinevi 2021-12-01
Series:Mediterranean Journal of Infection, Microbes and Antimicrobials
Subjects:
thiadiazole
aspergillus fumigatus
ergosterol
antifungal activity
electron microscopy
cytotoxicity
Online Access:http://mjima.org/abstract.php?id=258

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http://mjima.org/abstract.php?id=258

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