Effect of the N501Y Mutation on Ligands Complexed with SARS-CoV-2 RBD: Insights on Potential Drug Candidates for COVID-19

Effect of the N501Y Mutation on Ligands Complexed with SARS-CoV-2 RBD: Insights on Potential Drug Candidates for COVID-19

Bioactive compounds against SARS-CoV-2 targets could be potential treatments for COVID-19. Inhibitors of the receptor-binding domain (RBD) on the viral spike protein can block its binding to the human angiotensin-converting enzyme type II (ACE2) receptor. This study presents ligands based on natural...

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Bibliographic Details
Main Authors: Camila Fonseca Amorim da Silva, Samanta Omae Camalhonte, Michell de Oliveira Almeida, Sheila Cruz Araujo, Miriam Sannomiya, João Henrique Ghilardi Lago, Kathia Maria Honorio
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Drugs and Drug Candidates
Subjects:
COVID-19
SARS-CoV-2
spike
drug discovery
in silico strategies
docking
Online Access:https://www.mdpi.com/2813-2998/2/2/22

Internet

https://www.mdpi.com/2813-2998/2/2/22

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