Lactate Dehydrogenase Inhibitors Suppress <i>Borrelia burgdorferi</i> Growth In Vitro

<i>Borrelia burgdorferi</i>, the causative agent of Lyme disease, has a highly reduced genome and relies heavily on glycolysis for carbon metabolism. As such, established inhibitors of lactate dehydrogenase (LDH) were evaluated in cultures to determine the extent of their impacts on <...

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Bibliographic Details
Main Authors: Adam Lynch, Patrick Pearson, Sergey N. Savinov, Andrew Y. Li, Stephen M. Rich
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pathogens
Subjects:
Online Access:https://www.mdpi.com/2076-0817/12/7/962