Colocalization of IgG and IgA Heavy Chains with Kappa and Lambda Light Chains in Glomerular Deposits of IgA Nephropathy Patients Using High-Resolution Confocal Microscopy and Correlation with Oxford MEST-C Scores

Colocalization of IgG and IgA Heavy Chains with Kappa and Lambda Light Chains in Glomerular Deposits of IgA Nephropathy Patients Using High-Resolution Confocal Microscopy and Correlation with Oxford MEST-C Scores

Routine immunofluorescence microscopy of glomerular immunodeposits in IgA nephropathy shows IgA, C3, and lambda light chains, and sometimes IgG, IgM, and kappa light chains. However, a previous study using high-resolution confocal microscopy showed IgG in all IgA nephropathy cases, likely representi...

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Bibliographic Details
Main Authors: Dana V. Rizk, Lea Novak, Stacy D. Hall, Zina Moldoveanu, Bruce A. Julian, Jan Novak, Mark Haas
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Journal of Clinical Medicine
Subjects:
IgA nephropathy
IgAN
immune complexes
light chains
confocal microscopy
MEST-C scores
Online Access:https://www.mdpi.com/2077-0383/12/23/7361

Internet

https://www.mdpi.com/2077-0383/12/23/7361

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